Over the last two decades, the global community has come to recognise the profound impact of violence on the lives of women and girls. This fundamentally undermines their health and well-being, and stands as a barrier to women’s full participation in global development and the economic and civic life of their communities. This evidence brief outlines the effective design and implementation elements in interventions to prevent violence against women and girls emanating from the UKAID-funded, What Works to Prevent Violence Against Women and Girls (What Works) programme, a six-year, £25-million investment in VAWG prevention.